Alzheimer's disease-associated reduction of polysomal mRNA translation

NS Langstrom, JP Anderson, HG Lindroos… - Molecular Brain …, 1989 - Elsevier
Polysomes from the frontal cortices of individuals who had histopathologically confirmed
Alzheimer's disease were compared with polysomes from individuals who exhibited no
neuropathological conditions. The cytosolic polysome yield from Alzheimer's disease frontal
cortex was reduced 40% compared with that obtained from control frontal cortex. The
translational activity per unit polysome of the Alzheimer's disease polysomes was only 50%
of control in a reticulocyte lysate in vitro translation assay in which human polysomes do not …