Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease
T Ma, E Klann - Journal of neurochemistry, 2012 - Wiley Online Library
T Ma, E Klann
Journal of neurochemistry, 2012•Wiley Online LibraryJ. Neurochem.(2012) 120 (Suppl. 1), 140–148. Abstract Mounting evidence suggests that
amyloid beta‐induced impairments in synaptic plasticity that is accompanied by cognitive
decline and dementia represent key pathogenic steps of Alzheimer's disease. In this study,
we review recent advances in the study of the molecular and cellular mechanisms
underlying Alzheimer's disease‐associated synaptic dysfunction and memory deficits, and
how these mechanisms could provide novel avenues for therapeutic intervention to treat this …
amyloid beta‐induced impairments in synaptic plasticity that is accompanied by cognitive
decline and dementia represent key pathogenic steps of Alzheimer's disease. In this study,
we review recent advances in the study of the molecular and cellular mechanisms
underlying Alzheimer's disease‐associated synaptic dysfunction and memory deficits, and
how these mechanisms could provide novel avenues for therapeutic intervention to treat this …
J. Neurochem. (2012) 120 (Suppl. 1), 140–148.
Abstract
Mounting evidence suggests that amyloid beta‐induced impairments in synaptic plasticity that is accompanied by cognitive decline and dementia represent key pathogenic steps of Alzheimer’s disease. In this study, we review recent advances in the study of the molecular and cellular mechanisms underlying Alzheimer’s disease‐associated synaptic dysfunction and memory deficits, and how these mechanisms could provide novel avenues for therapeutic intervention to treat this devastating neurodegenerative disease.
Wiley Online Library