IL-17A enhances IL-13 activity by enhancing IL-13–induced signal transducer and activator of transcription 6 activation
SL Hall, T Baker, S Lajoie, PK Richgels, Y Yang… - Journal of Allergy and …, 2017 - Elsevier
Background Increased IL-17A production has been associated with more severe asthma;
however, the mechanisms whereby IL-17A can contribute to IL-13–driven pathology in
asthmatic patients remain unclear. Objective We sought to gain mechanistic insight into how
IL-17A can influence IL-13–driven responses. Methods The effect of IL-17A on IL-13–
induced airway hyperresponsiveness, gene expression, mucus hypersecretion, and airway
inflammation was assessed by using in vivo models of IL-13–induced lung pathology and in …
however, the mechanisms whereby IL-17A can contribute to IL-13–driven pathology in
asthmatic patients remain unclear. Objective We sought to gain mechanistic insight into how
IL-17A can influence IL-13–driven responses. Methods The effect of IL-17A on IL-13–
induced airway hyperresponsiveness, gene expression, mucus hypersecretion, and airway
inflammation was assessed by using in vivo models of IL-13–induced lung pathology and in …