[HTML][HTML] Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle

T Palmai-Pallag, CZ Bachrati - Microbes and infection, 2014 - Elsevier
Inflammation is the ultimate response to the constant challenges of the immune system by
microbes, irritants or injury. The inflammatory cascade initiates with the recognition of
microorganism-derived pathogen associated molecular patterns (PAMPs) and host cell-
derived damage associated molecular patterns (DAMPs) by the pattern recognition
receptors (PRRs). DNA as a molecular PAMP or DAMP is sensed directly or via specific
binding proteins to instigate pro-inflammatory response. Some of these DNA binding …