Molecular pathways driving disease-specific alterations of intestinal epithelial cells
R López-Posadas, MF Neurath, I Atreya - Cellular and Molecular Life …, 2017 - Springer
R López-Posadas, MF Neurath, I Atreya
Cellular and Molecular Life Sciences, 2017•SpringerDue to the fact that chronic inflammation as well as tumorigenesis in the gut is crucially
impacted by the fate of intestinal epithelial cells, our article provides a comprehensive
overview of the composition, function, regulation and homeostasis of the gut epithelium. In
particular, we focus on those aspects which were found to be altered in the context of
inflammatory bowel diseases or colorectal cancer and also discuss potential molecular
targets for a disease-specific therapeutic intervention.
impacted by the fate of intestinal epithelial cells, our article provides a comprehensive
overview of the composition, function, regulation and homeostasis of the gut epithelium. In
particular, we focus on those aspects which were found to be altered in the context of
inflammatory bowel diseases or colorectal cancer and also discuss potential molecular
targets for a disease-specific therapeutic intervention.
Abstract
Due to the fact that chronic inflammation as well as tumorigenesis in the gut is crucially impacted by the fate of intestinal epithelial cells, our article provides a comprehensive overview of the composition, function, regulation and homeostasis of the gut epithelium. In particular, we focus on those aspects which were found to be altered in the context of inflammatory bowel diseases or colorectal cancer and also discuss potential molecular targets for a disease-specific therapeutic intervention.
Springer