[HTML][HTML] Deletion of the distal C terminus of CaV1. 2 channels leads to loss of β-adrenergic regulation and heart failure in vivo
Y Fu, RE Westenbroek, HY Frank, JP Clark… - Journal of Biological …, 2011 - ASBMB
L-type calcium currents conducted by Ca V 1.2 channels initiate excitation-contraction
coupling in cardiac and vascular smooth muscle. In the heart, the distal portion of the C
terminus (DCT) is proteolytically processed in vivo and serves as a noncovalently
associated autoinhibitor of Ca V 1.2 channel activity. This autoinhibitory complex, with A-
kinase anchoring protein-15 (AKAP15) bound to the DCT, is hypothesized to serve as the
substrate for β-adrenergic regulation in the fight-or-flight response. Mice expressing Ca V …
coupling in cardiac and vascular smooth muscle. In the heart, the distal portion of the C
terminus (DCT) is proteolytically processed in vivo and serves as a noncovalently
associated autoinhibitor of Ca V 1.2 channel activity. This autoinhibitory complex, with A-
kinase anchoring protein-15 (AKAP15) bound to the DCT, is hypothesized to serve as the
substrate for β-adrenergic regulation in the fight-or-flight response. Mice expressing Ca V …