Auxiliary subunits: essential components of the voltage-gated calcium channel complex
J Arikkath, KP Campbell - Current opinion in neurobiology, 2003 - Elsevier
J Arikkath, KP Campbell
Current opinion in neurobiology, 2003•ElsevierVoltage-gated calcium channels are important mediators of several physiological processes,
including neuronal excitability and muscle contraction. At the molecular level, the channels
are composed of four subunits—the pore forming α1 subunit and the auxiliary α2δ, β and γ
subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the
α1 subunit. In the past several years there has been an acceleration of our understanding of
the auxiliary subunits, primarily because of their molecular characterization and the …
including neuronal excitability and muscle contraction. At the molecular level, the channels
are composed of four subunits—the pore forming α1 subunit and the auxiliary α2δ, β and γ
subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the
α1 subunit. In the past several years there has been an acceleration of our understanding of
the auxiliary subunits, primarily because of their molecular characterization and the …
Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the channels are composed of four subunits — the pore forming α1 subunit and the auxiliary α2δ, β and γ subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the α1 subunit. In the past several years there has been an acceleration of our understanding of the auxiliary subunits, primarily because of their molecular characterization and the availability of spontaneous and targeted mouse mutants. These studies have revealed the crucial role of the subunits in the functional effects that are mediated by voltage-gated calcium channels.
Elsevier