[HTML][HTML] Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

K Hu, S Babapoor-Farrokhran, M Rodrigues… - Oncotarget, 2016 - ncbi.nlm.nih.gov
K Hu, S Babapoor-Farrokhran, M Rodrigues, M Deshpande, B Puchner, F Kashiwabuchi…
Oncotarget, 2016ncbi.nlm.nih.gov
Purpose Expression of the hypoxia-inducible factor (HIF)-1-regulated gene product, vascular
endothelial growth factor (VEGF), correlates with tumor vascularity in patients with uveal
melanoma (UM). While the relationship between HIF-1 and VEGF in cancer is well-studied,
their relative contribution to the angiogenic phenotype in UM has not previously been
interrogated. Here we evaluate the contribution of HIF-1, VEGF, and a second HIF-1-
regulated gene product, angiopoietin-like 4 (ANGPTL4), to angiogenesis in UM.
Abstract
Purpose
Expression of the hypoxia-inducible factor (HIF)-1-regulated gene product, vascular endothelial growth factor (VEGF), correlates with tumor vascularity in patients with uveal melanoma (UM). While the relationship between HIF-1 and VEGF in cancer is well-studied, their relative contribution to the angiogenic phenotype in UM has not previously been interrogated. Here we evaluate the contribution of HIF-1, VEGF, and a second HIF-1-regulated gene product, angiopoietin-like 4 (ANGPTL4), to angiogenesis in UM.
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