[HTML][HTML] Second malignant neoplasms in patients with Cowden syndrome with underlying germline PTEN mutations

J Ngeow, K Stanuch, JL Mester… - Journal of Clinical …, 2014 - ncbi.nlm.nih.gov
J Ngeow, K Stanuch, JL Mester, JS Barnholtz-Sloan, C Eng
Journal of Clinical Oncology, 2014ncbi.nlm.nih.gov
Second Malignant Neoplasms in Patients With Cowden Syndrome With Underlying Germline
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Abstract
Purpose
Patients with Cowden syndrome (CS) with underlying germline PTEN mutations are at increased risk of breast, thyroid, endometrial, and renal cancers. To our knowledge, risk of subsequent cancers in these patients has not been previously explored or quantified.
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