Landscape of phosphatidylinositol-3-kinase pathway alterations across 19 784 diverse solid tumors
SZ Millis, S Ikeda, S Reddy, Z Gatalica… - JAMA oncology, 2016 - jamanetwork.com
Importance Molecular aberrations in the phosphatidylinositol-3-kinase (PI3K) pathway drive
tumorigenesis. Frequently co-occurring alterations in hormone receptors and/or human
epidermal growth factor receptor 2 (HER2) may be relevant to mechanisms of response and
resistance. Objective To identify patterns of aberration in the PI3K and interactive pathways
that might lead to targeted therapy opportunities in clinical practice. Design, Setting, and
Participants From January 2013 through December 2014, 19 784 consecutive tumor …
tumorigenesis. Frequently co-occurring alterations in hormone receptors and/or human
epidermal growth factor receptor 2 (HER2) may be relevant to mechanisms of response and
resistance. Objective To identify patterns of aberration in the PI3K and interactive pathways
that might lead to targeted therapy opportunities in clinical practice. Design, Setting, and
Participants From January 2013 through December 2014, 19 784 consecutive tumor …