Anti-HLA class I antibody binding to airway epithelial cells induces production of fibrogenic growth factors and apoptotic cell death: a possible mechanism for …
A Jaramillo, CR Smith, T Maruyama, L Zhang… - Human immunology, 2003 - Elsevier
Development of anti-HLA class I antibodies is associated with bronchiolitis obliterans
syndrome (BOS) after lung transplantation. BOS is characterized histologically by significant
fibrosis and airway epithelial cell (AEC) apoptosis. Thus, this study was designed to
determine whether anti-HLA class I antibodies can activate AECs to produce growth factors
and to undergo apoptosis. KCC-266 AECs were activated with the W6/32 anti-HLA class I
monoclonal antibody. Proliferation and apoptosis levels were determined after 24, 48, and …
syndrome (BOS) after lung transplantation. BOS is characterized histologically by significant
fibrosis and airway epithelial cell (AEC) apoptosis. Thus, this study was designed to
determine whether anti-HLA class I antibodies can activate AECs to produce growth factors
and to undergo apoptosis. KCC-266 AECs were activated with the W6/32 anti-HLA class I
monoclonal antibody. Proliferation and apoptosis levels were determined after 24, 48, and …