Liver sinusoidal endothelial cells (LSECs) are involved in the transport of nutrients, lipids,
and lipoproteins, and LSEC injury occurs in various liver diseases including nonalcoholic
fatty liver disease (NAFLD). However, the association between LSEC injury and NAFLD
progression remains elusive. Accordingly, in this study, we aimed to elucidate the precise
role of LSEC in the pathophysiology of NAFLD using two different mouse models, namely
the choline-deficient, L-amino acid-defined and high-fat diet models. Administration of these …