Evidence for a reversal with age in the pattern of near-wall blood flow around aortic branches

SL Al-Musawi, J Bishton, J Dean, S Williams… - Atherosclerosis, 2004 - Elsevier
The changes that occur with age in the distribution of atherosclerotic lesions around arterial
branch points challenge accepted theories relating disease to haemodynamic stresses. We
investigated whether flow near branch points changes with age in a way that can account for
the different lesion distributions. Flow around 20 branches from immature and mature aortas
was investigated by examining the length: width ratio and orientation of endothelial nuclei;
these properties depend on the magnitude and direction of near-wall flows, respectively …