GATA-2 L359 V mutation is exclusively associated with CML progression but not other hematological malignancies and GATA-2 P250A is a novel single nucleotide …
SJ Zhang, JY Shi, JY Li - Leukemia research, 2009 - Elsevier
Chronic myeloid leukemia (CML) progression is characterized by occurrence of new
cytogenetic and molecular abnormalities. In the previous study, we have shown the
important role of GATA-2 L359 V mutation in CML progression. To further ascertain the truth
of transcription factor GATA-2 in hematological malignancies, we expanded our study to
GATA-2 full length by directly sequencing and applied MassARRAY assay into GATA-2
L359 V mutation analysis. Finally, no GATA-2 L359 V mutation was found in 270 acute …
cytogenetic and molecular abnormalities. In the previous study, we have shown the
important role of GATA-2 L359 V mutation in CML progression. To further ascertain the truth
of transcription factor GATA-2 in hematological malignancies, we expanded our study to
GATA-2 full length by directly sequencing and applied MassARRAY assay into GATA-2
L359 V mutation analysis. Finally, no GATA-2 L359 V mutation was found in 270 acute …