Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells
SF Tsai, DIK Martin, LI Zon, AD D'Andrea, GG Wong… - Nature, 1989 - nature.com
Genes expressed in erythroid cells contain binding sites for a cell-specific factor believed to
be an important regulator for this haematopoietic lineage. Using high-level transient
expression in mammalian cells, we have identified complementary DNA encoding the
murine protein. The factor, a new member of the zinc-finger family of DNA-binding proteins,
is restricted to erythroid cells at the level of RNA expression and is closely homologous
between mouse and man.
be an important regulator for this haematopoietic lineage. Using high-level transient
expression in mammalian cells, we have identified complementary DNA encoding the
murine protein. The factor, a new member of the zinc-finger family of DNA-binding proteins,
is restricted to erythroid cells at the level of RNA expression and is closely homologous
between mouse and man.
Abstract
Genes expressed in erythroid cells contain binding sites for a cell-specific factor believed to be an important regulator for this haematopoietic lineage. Using high-level transient expression in mammalian cells, we have identified complementary DNA encoding the murine protein. The factor, a new member of the zinc-finger family of DNA-binding proteins, is restricted to erythroid cells at the level of RNA expression and is closely homologous between mouse and man.
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