Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
MK Cooper, JA Porter, KE Young, PA Beachy - Science, 1998 - science.org
MK Cooper, JA Porter, KE Young, PA Beachy
Science, 1998•science.orgVeratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for
more than 30 years as potent teratogens capable of inducing cyclopia and other birth
defects. Here, it is shown that these compounds specifically block the Sonic hedgehog (Shh)
signaling pathway. These teratogens did not prevent the sterol modification of Shh during
autoprocessing but rather inhibited the response of target tissues to Shh, possibly acting
through the sterol sensing domain within the Patched protein regulator of Shh response.
more than 30 years as potent teratogens capable of inducing cyclopia and other birth
defects. Here, it is shown that these compounds specifically block the Sonic hedgehog (Shh)
signaling pathway. These teratogens did not prevent the sterol modification of Shh during
autoprocessing but rather inhibited the response of target tissues to Shh, possibly acting
through the sterol sensing domain within the Patched protein regulator of Shh response.
Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for more than 30 years as potent teratogens capable of inducing cyclopia and other birth defects. Here, it is shown that these compounds specifically block the Sonic hedgehog (Shh) signaling pathway. These teratogens did not prevent the sterol modification of Shh during autoprocessing but rather inhibited the response of target tissues to Shh, possibly acting through the sterol sensing domain within the Patched protein regulator of Shh response.
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