[HTML][HTML] Reciprocal interactions regulate targeting of calcium channel β subunits and membrane expression of α1 subunits in cultured hippocampal neurons
GJ Obermair, B Schlick, V Di Biase… - Journal of biological …, 2010 - ASBMB
Auxiliary β subunits modulate current properties and mediate the functional membrane
expression of voltage-gated Ca 2+ channels in heterologous cells. In brain, all four β
isoforms are widely expressed, yet little is known about their specific roles in neuronal
functions. Here, we investigated the expression and targeting properties of β subunits and
their role in membrane expression of Ca V 1.2 α 1 subunits in cultured hippocampal
neurons. Quantitative reverse transcription-PCR showed equal expression, and …
expression of voltage-gated Ca 2+ channels in heterologous cells. In brain, all four β
isoforms are widely expressed, yet little is known about their specific roles in neuronal
functions. Here, we investigated the expression and targeting properties of β subunits and
their role in membrane expression of Ca V 1.2 α 1 subunits in cultured hippocampal
neurons. Quantitative reverse transcription-PCR showed equal expression, and …