Angiotensin II receptor antagonism reduces transforming growth factor beta and smad signaling in thoracic aortic aneurysm

M Nataatmadja, J West, S Prabowo, M West - Ochsner Journal, 2013 - ochsnerjournal.org
Background The expression of transforming growth factor beta (TGF-β) and Smad3
regulates extracellular matrix homeostasis and inflammation in aortic aneurysms. The
expression of Smad3 depends on signaling by angiotensin II (AngII) receptor pathways
through TGF-β receptor–dependent and–independent pathways. Methods To determine the
expression of AngII type 1 (AT1R) and type 2 receptors (AT2R), TGF-β, and Smad3 in
thoracic aortic aneurysms, we performed immunohistochemistry testing on tissue and …