[HTML][HTML] The proinflammatory actions of angiotensin II are dependent on p65 phosphorylation by the IκB kinase complex
A Douillette, A Bibeau-Poirier, SP Gravel… - Journal of Biological …, 2006 - ASBMB
The vasoactive hormone angiotensin II (Ang II) probably triggers inflammatory
cardiovascular diseases by activating transcription factors such as NF-κB. We describe here
a novel mode of NF-κB activation in cultured vascular smooth muscle cells exposed to Ang
II. Ang II treatment resulted in an increase in the phosphotransferase activity of the IKK
complex, which was mediated through the AT1 receptor subtype. The typical
phosphorylation and proteasome-dependent degradation of the NF-κB inhibitor IκBα were …
cardiovascular diseases by activating transcription factors such as NF-κB. We describe here
a novel mode of NF-κB activation in cultured vascular smooth muscle cells exposed to Ang
II. Ang II treatment resulted in an increase in the phosphotransferase activity of the IKK
complex, which was mediated through the AT1 receptor subtype. The typical
phosphorylation and proteasome-dependent degradation of the NF-κB inhibitor IκBα were …