In vivo anti-complementary activities of the cobra venom factors from Naja naja and Naja haje
CW Van den Berg, PC Aerts, H Van Dijk - Journal of immunological …, 1991 - Elsevier
The kinetics of complement (C) depletion and recovery of C levels upon injection of BALB/c
mice with cobra venom factors (CVF), from N. naja (C3-and C5-depleting) and N. haje
(selectively C3-depleting) were studied. The animals received ip or iv injections of either of
the two preparations. CH50 and hemolytic C3 and C5 levels were followed as parameters of
residual complement activity. N. naja CVF turned out to be as efficient in depleting total
complement activity as N. haje CVF. Decreased CH50 values could largely be ascribed to …
mice with cobra venom factors (CVF), from N. naja (C3-and C5-depleting) and N. haje
(selectively C3-depleting) were studied. The animals received ip or iv injections of either of
the two preparations. CH50 and hemolytic C3 and C5 levels were followed as parameters of
residual complement activity. N. naja CVF turned out to be as efficient in depleting total
complement activity as N. haje CVF. Decreased CH50 values could largely be ascribed to …