Regulation of erythropoiesis by hypoxia-inducible factors

VH Haase - Blood reviews, 2013 - Elsevier
A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type
specific gene expression changes that result in increased erythropoietin (EPO) production in
kidney and liver, in enhanced iron uptake and utilization and in adjustments of the bone
marrow microenvironment that facilitate erythroid progenitor maturation and proliferation. In
particular HIF-2 has emerged as the transcription factor that regulates EPO synthesis in the …