Antidepressant action of HDAC inhibition in the prefrontal cortex

HE Covington III, I Maze, V Vialou, EJ Nestler - Neuroscience, 2015 - Elsevier
Neuroscience, 2015Elsevier
Previous research has demonstrated antidepressant-like effects in rodents upon
intracerebral inhibition of histone deacetylases (HDACs). Such effects have been reported
for local HDAC inhibition in the nucleus accumbens, hippocampus, and amygdala.
However, the effect of HDAC inhibition within the medial prefrontal cortex, which is integral
to depression-related symptoms and their treatment, remains unknown. Here we show that
local infusion of the highly selective HDAC inhibitor, MS-275, into the medial prefrontal …
Abstract
Previous research has demonstrated antidepressant-like effects in rodents upon intracerebral inhibition of histone deacetylases (HDACs). Such effects have been reported for local HDAC inhibition in the nucleus accumbens, hippocampus, and amygdala. However, the effect of HDAC inhibition within the medial prefrontal cortex, which is integral to depression-related symptoms and their treatment, remains unknown. Here we show that local infusion of the highly selective HDAC inhibitor, MS-275, into the medial prefrontal cortex exerts robust antidepressant-like effects in the chronic social defeat stress paradigm in mice. These findings provide further impetus for the assessment of HDAC inhibitors for the treatment of depression.
Elsevier