[HTML][HTML] Mechanisms of thyroid hormone action

GA Brent - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
GA Brent
The Journal of clinical investigation, 2012Am Soc Clin Investig
Our understanding of thyroid hormone action has been substantially altered by recent
clinical observations of thyroid signaling defects in syndromes of hormone resistance and in
a broad range of conditions, including profound mental retardation, obesity, metabolic
disorders, and a number of cancers. The mechanism of thyroid hormone action has been
informed by these clinical observations as well as by animal models and has influenced the
way we view the role of local ligand availability; tissue and cell-specific thyroid hormone …
Our understanding of thyroid hormone action has been substantially altered by recent clinical observations of thyroid signaling defects in syndromes of hormone resistance and in a broad range of conditions, including profound mental retardation, obesity, metabolic disorders, and a number of cancers. The mechanism of thyroid hormone action has been informed by these clinical observations as well as by animal models and has influenced the way we view the role of local ligand availability; tissue and cell-specific thyroid hormone transporters, corepressors, and coactivators; thyroid hormone receptor (TR) isoform–specific action; and cross-talk in metabolic regulation and neural development. In some cases, our new understanding has already been translated into therapeutic strategies, especially for treating hyperlipidemia and obesity, and other drugs are in development to treat cardiac disease and cancer and to improve cognitive function.
The Journal of Clinical Investigation