[HTML][HTML] Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in …

J Lu, S Guo, X Xue, Q Chen, J Ge, Y Zhuo… - Journal of Biological …, 2017 - ASBMB
Oxidative stress and inflammation are two major contributing factors to atherosclerosis, a
leading cause of cardiovascular disease. Oxidation of phospholipids on the surface of low
density lipoprotein (LDL) particles generated under oxidative stress has been associated
with the progression of atherosclerosis, but the underlying molecular mechanisms remain
poorly defined. We identified a novel series of oxidation products containing the
cyclopentenone moiety, termed deoxy-A 2/J 2-isoprostanes-phosphocholine, from 1 …