The genetic architecture of multiple myeloma

GJ Morgan, BA Walker, FE Davies - Nature Reviews Cancer, 2012 - nature.com
GJ Morgan, BA Walker, FE Davies
Nature Reviews Cancer, 2012nature.com
Based on the clinical features of myeloma and related malignancies of plasma cells, it has
been possible to generate a model system of myeloma progression from a normal plasma
cell through smouldering myeloma to myeloma and then plasma cell leukaemia. Using this
model system we can study at which points the genetic alterations identified through whole-
tumour molecular analyses function in the initiation and progression of myeloma. Further
genetic complexity, such as intraclonal heterogeneity, and insights into the molecular …
Abstract
Based on the clinical features of myeloma and related malignancies of plasma cells, it has been possible to generate a model system of myeloma progression from a normal plasma cell through smouldering myeloma to myeloma and then plasma cell leukaemia. Using this model system we can study at which points the genetic alterations identified through whole-tumour molecular analyses function in the initiation and progression of myeloma. Further genetic complexity, such as intraclonal heterogeneity, and insights into the molecular evolution and intraclonal dynamics in this model system are crucial to our understandings of tumour progression, treatment resistance and the use of currently available and future treatments.
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