Two tumour necrosis factor receptors: structure and function

P Vandenabeele, W Declercq, R Beyaert, W Fiers - Trends in cell biology, 1995 - cell.com
P Vandenabeele, W Declercq, R Beyaert, W Fiers
Trends in cell biology, 1995cell.com
Tumour necrosis factor (TNF) exerts two main effects: a beneficial one as an anti-infection,
anti-tumour cytokine, and a detrimental one in the systemic inflammatory response
syndrome (SIRS). Two receptors (TNF-R) mediate these effects, but their precise role in
different cell types is far from solved. TNF induces receptor oligomerization, an event that is
believed to connect the receptors to downstream signalling pathways. Recent research
suggests that several TNF-R-associated proteins, including kinases, may initiate cytoplasmic …
Abstract
Tumour necrosis factor (TNF) exerts two main effects: a beneficial one as an anti-infection, anti-tumour cytokine, and a detrimental one in the systemic inflammatory response syndrome (SIRS). Two receptors (TNF-R) mediate these effects, but their precise role in different cell types is far from solved. TNF induces receptor oligomerization, an event that is believed to connect the receptors to downstream signalling pathways. Recent research suggests that several TNF-R-associated proteins, including kinases, may initiate cytoplasmic signal transduction.
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