The intestinal immune system is chronically challenged by a huge plethora of antigens
derived from the lumen. B-cell responses in organized gut-associated lymphoid tissues and
regional lymph nodes that are driven chronically by gut antigens generate the largest
population of antibody-producing cells in the body: the gut lamina propria plasma cells.
Although animal studies have provided insights into mechanisms that underpin this dynamic
process, some very fundamental differences in this system appear to exist between species …