HIF at a glance

MC Brahimi-Horn, J Pouysségur - Journal of cell science, 2009 - journals.biologists.com
MC Brahimi-Horn, J Pouysségur
Journal of cell science, 2009journals.biologists.com
Hypoxia-inducible factor (HIF) is a sequence-specific DNA-binding protein that can promote
or repress the transcription of a broad range of genes that are involved in maintaining
biological homeostasis. HIF is mostly non-functional in oxygenated cells but becomes active
under specific conditions, including lowoxygen (hypoxic) stress. HIF is a heterodimeric
complex that is composed of an oxygen-destructible α-subunit and an oxygen-indestructible
β-subunit. Three isoforms of the α-subunit and two isoforms of the β-subunit are thought to …
Hypoxia-inducible factor (HIF) is a sequence-specific DNA-binding protein that can promote or repress the transcription of a broad range of genes that are involved in maintaining biological homeostasis. HIF is mostly non-functional in oxygenated cells but becomes active under specific conditions, including lowoxygen (hypoxic) stress. HIF is a heterodimeric complex that is composed of an oxygen-destructible α-subunit and an oxygen-indestructible β-subunit. Three isoforms of the α-subunit and two isoforms of the β-subunit are thought to be involved in the in vivo response to hypoxia.
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