Mitochondrial involvement in Parkinson's disease
M Orth, AHV Schapira - Neurochemistry international, 2002 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease. There is a lifetime risk of 1 in 40 for the development of PD and the
prevalence is about 1 in 350 in the Western world (Roman et al., 1995). Clinically, PD
presents with bradykinesia, rigidity and tremor as its classic features, most commonly with an
onset of symptoms between the fifth and seventh decade. Pathologically, PD is caused by
the degeneration of dopaminergic neurons in the substantia nigra pars compacta of the …
Alzheimer's disease. There is a lifetime risk of 1 in 40 for the development of PD and the
prevalence is about 1 in 350 in the Western world (Roman et al., 1995). Clinically, PD
presents with bradykinesia, rigidity and tremor as its classic features, most commonly with an
onset of symptoms between the fifth and seventh decade. Pathologically, PD is caused by
the degeneration of dopaminergic neurons in the substantia nigra pars compacta of the …