Mitochondrial DNA deletions in Alzheimer's brains: a review
NR Phillips, JW Simpkins, RK Roby - Alzheimer's & Dementia, 2014 - Elsevier
Mitochondrial dysfunction and increased oxidative stress have been associated with normal
aging and are possibly implicated in the etiology of late-onset Alzheimer's disease (AD).
DNA deletions, as well as other alterations, can result from oxidative damage to nucleic
acids. Many studies during the past two decades have investigated the incidence of
mitochondrial DNA deletions in postmortem brain tissues of late-onset AD patients
compared with age-matched normal control subjects. Published studies are not entirely …
aging and are possibly implicated in the etiology of late-onset Alzheimer's disease (AD).
DNA deletions, as well as other alterations, can result from oxidative damage to nucleic
acids. Many studies during the past two decades have investigated the incidence of
mitochondrial DNA deletions in postmortem brain tissues of late-onset AD patients
compared with age-matched normal control subjects. Published studies are not entirely …