No association between Alzheimer plaques and decreased levels of cytochrome oxidase subunit mRNA, a marker of neuronal energy metabolism
K Hatanpää, K Chandrasekaran, DR Brady… - Molecular brain …, 1998 - Elsevier
It has been proposed that neuritic plaques or toxic substances diffusing from them contribute
to neurodegeneration in Alzheimer disease. We examined this hypothesis by looking for
evidence of decreased neuronal energy metabolism in the proximity of neuritic plaques.
Levels of mitochondrial DNA-encoded mRNA for subunit III of cytochrome oxidase, a marker
of neuronal energy metabolism, were determined in post mortem brain samples. Consistent
with earlier results, overall cytochrome oxidase subunit III mRNA levels were decreased in …
to neurodegeneration in Alzheimer disease. We examined this hypothesis by looking for
evidence of decreased neuronal energy metabolism in the proximity of neuritic plaques.
Levels of mitochondrial DNA-encoded mRNA for subunit III of cytochrome oxidase, a marker
of neuronal energy metabolism, were determined in post mortem brain samples. Consistent
with earlier results, overall cytochrome oxidase subunit III mRNA levels were decreased in …