Mitochondrial DNA alterations as ageing-associated molecular events
YH Wei - Mutation Research/DNAging, 1992 - Elsevier
Mitochondrial DNA (mtDNA) is a naked double-stranded circular extrachromosomal genetic
element continuously exposed to the matrix that contains great amounts of reactive oxygen
species and free radicals. The age-dependent decline in the capability and capacity of
mitochondria to dispose these oxy-radicals will render mtDNA more vulnerable to mutations
during the ageing process. During the past 3 years, more than 10 different types of deletions
have been identified in the mtDNA of various tissues of old humans. Some of them were …
element continuously exposed to the matrix that contains great amounts of reactive oxygen
species and free radicals. The age-dependent decline in the capability and capacity of
mitochondria to dispose these oxy-radicals will render mtDNA more vulnerable to mutations
during the ageing process. During the past 3 years, more than 10 different types of deletions
have been identified in the mtDNA of various tissues of old humans. Some of them were …