Absence of the Mitochondrial A7237T Mutation in Parkinson′ s Disease
CB Lucking, S Kosel, P Mehraein… - … and biophysical research …, 1995 - Elsevier
CB Lucking, S Kosel, P Mehraein, MB Graeber
Biochemical and biophysical research communications, 1995•ElsevierIn recent years much has been speculated about a pathogenic role of mitochondrial defects
in Parkinson′ s disease. Ozawa et al.(BBRC 176, 938-946, 1991) have described an A/T
transversion at nucleotide 7237 of mitochondrial DNA affecting cytochrome-c-oxidase
(complex IV) of the respiratory chain that could contribute to the pathogenesis of PD.
Employing PCR based genomic sequencing and restriction enzyme analysis on 19 cases of
Lewy-body parkinsonism, we exclude this mutation as a common cause of Parkinson′ s …
in Parkinson′ s disease. Ozawa et al.(BBRC 176, 938-946, 1991) have described an A/T
transversion at nucleotide 7237 of mitochondrial DNA affecting cytochrome-c-oxidase
(complex IV) of the respiratory chain that could contribute to the pathogenesis of PD.
Employing PCR based genomic sequencing and restriction enzyme analysis on 19 cases of
Lewy-body parkinsonism, we exclude this mutation as a common cause of Parkinson′ s …
In recent years much has been speculated about a pathogenic role of mitochondrial defects in Parkinson′s disease. Ozawa et al. (BBRC 176, 938-946, 1991) have described an A/T transversion at nucleotide 7237 of mitochondrial DNA affecting cytochrome-c-oxidase (complex IV) of the respiratory chain that could contribute to the pathogenesis of PD. Employing PCR based genomic sequencing and restriction enzyme analysis on 19 cases of Lewy-body parkinsonism, we exclude this mutation as a common cause of Parkinson′s disease. This demonstrates the need for systematic sequencing of the mitochondrial genome in a large number of histologically verified cases of Parkinson′s disease.
Elsevier
