Lipid transport between the endoplasmic reticulum and mitochondria

VV Flis, G Daum - Cold Spring Harbor perspectives in …, 2013 - cshperspectives.cshlp.org
VV Flis, G Daum
Cold Spring Harbor perspectives in biology, 2013cshperspectives.cshlp.org
Mitochondria are partially autonomous organelles that depend on the import of certain
proteins and lipids to maintain cell survival and membrane formation. Although
phosphatidylglycerol, cardiolipin, and phosphatidylethanolamine are synthesized by
mitochondrial enzymes, phosphatidylcholine, phosphatidylinositol, phosphatidylserine, and
sterols need to be imported from other organelles. The origin of most lipids imported into
mitochondria is the endoplasmic reticulum, which requires interaction of these two …
Mitochondria are partially autonomous organelles that depend on the import of certain proteins and lipids to maintain cell survival and membrane formation. Although phosphatidylglycerol, cardiolipin, and phosphatidylethanolamine are synthesized by mitochondrial enzymes, phosphatidylcholine, phosphatidylinositol, phosphatidylserine, and sterols need to be imported from other organelles. The origin of most lipids imported into mitochondria is the endoplasmic reticulum, which requires interaction of these two subcellular compartments. Recently, protein complexes that are involved in membrane contact between endoplasmic reticulum and mitochondria were identified, but their role in lipid transport is still unclear. In the present review, we describe components involved in lipid translocation between the endoplasmic reticulum and mitochondria and discuss functional as well as regulatory aspects that are important for lipid homeostasis.
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