Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide and is
at present, incurable. The accumulation of toxic amyloid-beta (Aβ) peptide aggregates in AD
brain are thought to trigger the extensive synaptic loss and neurodegeneration linked to
cognitive decline, an idea that underlies the 'amyloid hypothesis' of AD etiology in both the
familal (FAD) and sporadic forms of the disease. Mutations causing FAD also result in the
dysregulation of neuronal calcium (Ca2+) handling and may contribute to AD pathogenesis …