[HTML][HTML] Nicastrin, presenilin, APH-1, and PEN-2 form active γ-secretase complexes in mitochondria
CA Hansson, S Frykman, MR Farmery… - Journal of Biological …, 2004 - ASBMB
Mitochondria are central in the regulation of cell death. Apart from providing the cell with
ATP, mitochondria also harbor several death factors that are released upon apoptotic
stimuli. Alterations in mitochondrial functions, increased oxidative stress, and neurons dying
by apoptosis have been detected in Alzheimer's disease patients. These findings suggest
that mitochondria may trigger the abnormal onset of neuronal cell death in Alzheimer's
disease. We previously reported that presenilin 1 (PS1), which is often mutated in familial …
ATP, mitochondria also harbor several death factors that are released upon apoptotic
stimuli. Alterations in mitochondrial functions, increased oxidative stress, and neurons dying
by apoptosis have been detected in Alzheimer's disease patients. These findings suggest
that mitochondria may trigger the abnormal onset of neuronal cell death in Alzheimer's
disease. We previously reported that presenilin 1 (PS1), which is often mutated in familial …