Akt as a victim, villain and potential hero in Parkinson's disease pathophysiology and treatment
LA Greene, O Levy, C Malagelada - Cellular and molecular neurobiology, 2011 - Springer
LA Greene, O Levy, C Malagelada
Cellular and molecular neurobiology, 2011•SpringerThere are two major purposes of this essay. The first is to summarize existing evidence that
irrespective of the initiating causes, neuron death and degeneration in Parkinson's disease
(PD) are due to the common feature of failure of signaling by Akt, a kinase involved in
neuron survival and maintenance of synaptic contacts. The second is to consider possible
means by which such a failure of Akt signaling might be benignly prevented or reversed in
neurons affected by PD, so as to treat PD symptoms, block disease progression, and …
irrespective of the initiating causes, neuron death and degeneration in Parkinson's disease
(PD) are due to the common feature of failure of signaling by Akt, a kinase involved in
neuron survival and maintenance of synaptic contacts. The second is to consider possible
means by which such a failure of Akt signaling might be benignly prevented or reversed in
neurons affected by PD, so as to treat PD symptoms, block disease progression, and …
Abstract
There are two major purposes of this essay. The first is to summarize existing evidence that irrespective of the initiating causes, neuron death and degeneration in Parkinson’s disease (PD) are due to the common feature of failure of signaling by Akt, a kinase involved in neuron survival and maintenance of synaptic contacts. The second is to consider possible means by which such a failure of Akt signaling might be benignly prevented or reversed in neurons affected by PD, so as to treat PD symptoms, block disease progression, and potentially, promote recovery.
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