Dopamine-containing neurons are silenced by energy deprivation: a defensive response or beginning of cell death?
E Guatteo, S Marinelli, R Geracitano, A Tozzi… - Neurotoxicology, 2005 - Elsevier
Metabolic stress associated to mitochondrial dysfunction has been put forward as an
important factor causing degeneration of mesencephalic dopamine-containing neurons in
Parkinson's disease (PD). Here we overview how these neurons react to acute hypoxia or
hypoglycemia, that are conditions of energy deprivation causing a reduced production of
ATP by mitochondria. These neurons, which show a tonic firing discharge under normal
condition, undergo into membrane hyperpolarization during hypoxia or hypoglycemia that …
important factor causing degeneration of mesencephalic dopamine-containing neurons in
Parkinson's disease (PD). Here we overview how these neurons react to acute hypoxia or
hypoglycemia, that are conditions of energy deprivation causing a reduced production of
ATP by mitochondria. These neurons, which show a tonic firing discharge under normal
condition, undergo into membrane hyperpolarization during hypoxia or hypoglycemia that …