[HTML][HTML] Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes
DJ Roberts, VP Tan-Sah, JM Smith… - Journal of Biological …, 2013 - ASBMB
Hexokinase II (HK-II) is an enzyme that catalyzes the first step in glycolysis and localizes not
only in the cytosol but also at mitochondria. Akt, activated by insulin-like growth factor 1 (IGF-
1) treatment in neonatal rat ventricular myocytes, translocates to mitochondria and increases
mitochondrial HK-II binding. Expression of an HK-II-dissociating peptide diminished IGF-1-
induced increases in mitochondrial HK-II as well as protection against hydrogen peroxide
treatment, suggesting an important role of mitochondrial HK-II in IGF-1/Akt-mediated …
only in the cytosol but also at mitochondria. Akt, activated by insulin-like growth factor 1 (IGF-
1) treatment in neonatal rat ventricular myocytes, translocates to mitochondria and increases
mitochondrial HK-II binding. Expression of an HK-II-dissociating peptide diminished IGF-1-
induced increases in mitochondrial HK-II as well as protection against hydrogen peroxide
treatment, suggesting an important role of mitochondrial HK-II in IGF-1/Akt-mediated …