3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model
Background & Aims Liver biopsy, the gold standard for assessing liver fibrosis, suffers from
limitations due to sampling error and invasiveness. There is therefore a critical need for
methods to non-invasively quantify fibrosis throughout the entire liver. The goal of this study
was to use molecular Magnetic Resonance Imaging (MRI) of Type I collagen to non-
invasively image liver fibrosis and assess response to rapamycin therapy. Methods Liver
fibrosis was induced in rats by bile duct ligation (BDL). MRI was performed 4, 10, or 18 days …
limitations due to sampling error and invasiveness. There is therefore a critical need for
methods to non-invasively quantify fibrosis throughout the entire liver. The goal of this study
was to use molecular Magnetic Resonance Imaging (MRI) of Type I collagen to non-
invasively image liver fibrosis and assess response to rapamycin therapy. Methods Liver
fibrosis was induced in rats by bile duct ligation (BDL). MRI was performed 4, 10, or 18 days …