[HTML][HTML] Glycoprotein VI in securing vascular integrity in inflamed vessels
Y Boulaftali, MA Mawhin, M Jandrot‐Perrus… - Research and practice …, 2018 - Elsevier
Essentials• Platelets can stop bleeding independently of integrin‐mediated aggregation in
inflamed organs.• GPVI contributes to aggregation‐independent hemostasis in the inflamed
skin.• GPVI supports sealing of neutrophil‐induced vascular breaches by nonaggregated
platelets.• Evaluation of anti‐GPVI drugs should take into account the risk of inflammatory
bleeding. Force Hémato 708973 INCA La Fondation Arc PJA 20151203107 La Fondation
pour la Recherche Medicale FRM ARF20140129191 Marie Curie Action 708973 DHU Fire …
inflamed organs.• GPVI contributes to aggregation‐independent hemostasis in the inflamed
skin.• GPVI supports sealing of neutrophil‐induced vascular breaches by nonaggregated
platelets.• Evaluation of anti‐GPVI drugs should take into account the risk of inflammatory
bleeding. Force Hémato 708973 INCA La Fondation Arc PJA 20151203107 La Fondation
pour la Recherche Medicale FRM ARF20140129191 Marie Curie Action 708973 DHU Fire …