Fucoidan, a sulfated polysaccharide from Fucus vesiculosus, decreases bleeding time and
clotting time in hemophilia, possibly through inhibition of tissue factor pathway inhibitor.
However, its effect on platelets and the receptor by which fucoidan induces cellular
processes has not been elucidated. In this study, we demonstrate that fucoidan induces
platelet activation in a concentration-dependent manner. Fucoidan-induced platelet
activation was completely abolished by the pan-Src family kinase (SFK) inhibitor, PP2, or …