[HTML][HTML] Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells
The interaction of C-type lectin receptor 2 (CLEC-2) on platelets with Podoplanin on
lymphatic endothelial cells initiates platelet signaling events that are necessary for
prevention of blood-lymph mixing during development. In the present study, we show that
CLEC-2 signaling via Src family and Syk tyrosine kinases promotes platelet adhesion to
primary mouse lymphatic endothelial cells at low shear. Using supported lipid bilayers
containing mobile Podoplanin, we further show that activation of Src and Syk in platelets …
lymphatic endothelial cells initiates platelet signaling events that are necessary for
prevention of blood-lymph mixing during development. In the present study, we show that
CLEC-2 signaling via Src family and Syk tyrosine kinases promotes platelet adhesion to
primary mouse lymphatic endothelial cells at low shear. Using supported lipid bilayers
containing mobile Podoplanin, we further show that activation of Src and Syk in platelets …