[HTML][HTML] C‐type lectin‐like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor‐bearing mice
T Shirai, O Inoue, S Tamura, N Tsukiji, T Sasaki… - Journal of Thrombosis …, 2017 - Elsevier
Essentials• The role of C‐type lectin‐like receptor‐2 (CLEC‐2) in cancer progression is
unclear.• CLEC‐2‐depleted mouse model is generated by using a rat anti‐mouse CLEC‐2
monoclonal antibody.• CLEC‐2 depletion inhibits hematogenous tumor metastasis of
podoplanin‐expressing B16F10 cells.• CLEC‐2 depletion prolongs cancer survival by
suppressing thrombosis and inflammation. Summary: Background C‐type lectin‐like
receptor 2 (CLEC‐2) is a platelet activation receptor of sialoglycoprotein podoplanin, which …
unclear.• CLEC‐2‐depleted mouse model is generated by using a rat anti‐mouse CLEC‐2
monoclonal antibody.• CLEC‐2 depletion inhibits hematogenous tumor metastasis of
podoplanin‐expressing B16F10 cells.• CLEC‐2 depletion prolongs cancer survival by
suppressing thrombosis and inflammation. Summary: Background C‐type lectin‐like
receptor 2 (CLEC‐2) is a platelet activation receptor of sialoglycoprotein podoplanin, which …