Cancer-associated mortality is frequently caused by metastasis, however, our understanding
of this process remains incomplete and therapeutic options are limited. Metastasis is a
dynamic multi-step process involving intravasation of tumor cells into the host's blood and
lymphatic vessels, their dissemination within the circulation, and finally arrest and
extravasation in a distant organ where they establish secondary tumors. It is generally
conceived that platelets contribute to all steps of hematogenous tumor dissemination. In this …