Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: a potential mechanism for amplification of inflammatory responses in …

J Hsu, Y Gu, SL Tan, S Narula, JA DeMartino, C Liao - Immunology letters, 2013 - Elsevier
Platelet microparticles (pMPs) are small membrane-coated vesicles that are released from
the plasma membrane upon platelet activation. In the joint fluid of patients with rheumatoid
arthritis, pMP can interact with and activate fibroblast-like synoviocytes (FLS), which are
important effector cells that mediate both immune activation and joint destruction. The
signaling process by which engagement of glycoprotein VI (GPVI), a surface glycoprotein
receptor for collagen which is expressed on platelets, triggers pMP generation is poorly …