[HTML][HTML] Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression …
P Zhang, K Takeuchi, LS Csaki, K Reue - Journal of Biological Chemistry, 2012 - ASBMB
Adipose tissue plays a key role in metabolic homeostasis. Disruption of the Lpin1 gene
encoding lipin-1 causes impaired adipose tissue development and function in rodents. Lipin-
1 functions as a phosphatidate phosphatase (PAP) enzyme in the glycerol 3-phosphate
pathway for triglyceride storage and as a transcriptional coactivator/corepressor for
metabolic nuclear receptors. Previous studies established that lipin-1 is required at an early
step in adipocyte differentiation for induction of the adipogenic gene transcription program …
encoding lipin-1 causes impaired adipose tissue development and function in rodents. Lipin-
1 functions as a phosphatidate phosphatase (PAP) enzyme in the glycerol 3-phosphate
pathway for triglyceride storage and as a transcriptional coactivator/corepressor for
metabolic nuclear receptors. Previous studies established that lipin-1 is required at an early
step in adipocyte differentiation for induction of the adipogenic gene transcription program …