We previously identified mutations in the Lpin1 gene, encoding lipin-1, as the underlying
cause of lipodystrophy in the fatty liver dystrophy (fld) mutant mouse. Lipin-1 is normally
expressed at high levels in adipose tissue and skeletal muscle, and deficiency in the fld
mouse causes impaired adipose tissue development, insulin resistance, and altered energy
expenditure. We also identified two additional lipin protein family members of unknown
function, lipin-2 and lipin-3. Han et al.(Han, GS, Wu, WI, and Carman, GM (2006) J. Biol …