The macrophage mediates the renoprotective effects of endotoxin preconditioning

T Hato, S Winfree, R Kalakeche, S Dube… - Journal of the …, 2015 - journals.lww.com
Preconditioning is a preventative approach, whereby minimized insults generate protection
against subsequent larger exposures to the same or even different insults. In immune cells,
endotoxin preconditioning downregulates the inflammatory response and yet, preserves the
ability to contain infections. However, the protective mechanisms of preconditioning at the
tissue level in organs such as the kidney remain poorly understood. Here, we show that
endotoxin preconditioning confers renal epithelial protection in various models of sepsis in …