[HTML][HTML] The pioneer round of translation: features and functions

LE Maquat, WY Tarn, O Isken - Cell, 2010 - cell.com
LE Maquat, WY Tarn, O Isken
Cell, 2010cell.com
In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that
is important for mRNA quality control. Following maturation of messenger ribonucleoprotein
particles during and after the pioneer round, steady-state cycles of mRNA translation
generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of
signaling pathways that are particular to newly synthesized mRNAs regulate critical
functions of the pioneer round.
In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.
cell.com